Objective
Overdominance occurs when individuals carrying two different alleles at a specific locus have higher Darwinian fitness than both homozygotes, who carry only one allele. It is involved in a range of observations in genetics and evolution (e.g. genetic diversity, inbreeding depression, heterosis) and has been controversial for over a century. Empirical studies on the frequency of spontaneous mutations causing overdominance are scarce and there has been no systematic effort to screen for overdominant alleles in any natural population. We propose to (1) test a recent theory predicting that the rate of spontaneous mutations with overdominant effect on fitness increases with maladaptation, and (2) screen for overdominance alleles in a natural population. We propose to use the most appropriate model system for answering each of these questions: Saccharomyces yeast for spontaneous mutations, and Daphnia for segregating alleles. Cutting-edge methods in experimental evolution and quantitative genetics will be used. This project will contribute to the scientific competitiveness of Europe by strengthening a new area of research in France (the scientist in charge will maintain permanent projects using experimental evolution with yeast), providing large libraries of yeast and Daphnia genotypes, and producing high-impact publications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.