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Structural preferences of histone variants during chromatin assembly in Physarum polycephalum

Final Report Summary - CHROMAPHY (Structural preferences of histone variants during chromatin assembly in Physarum polycephalum.)

The ChromaPhy project was an EU-funded research project supporting one post-doctoral fellow at the Ludwig-Maximilians University of Munich for 20 months. The project was funded under the EU's 7th framework programme as a Marie Curie Intra-European Fellowship (IEF), and ran from January 1st, 2014 until August 31st, 2015.

ChromaPhy's research focused on mechanisms of epigenetic inheritance. By combining novel techniques in chemical biology and live-cell imaging, we have developed a novel method to incorporate synthetic histones into chromatin. We have pioneered the use of the organism Physarum polycephalum as a model for studying this incorporation. This research has led to the development of novel reagents that can be used to probe components of the chromatin assembly pathway. Our detailed results will be disseminated as a peer-reviewed publication in the research literature, and the novel reagents are immediately available on request to interested researchers.