Final Report Summary - CHROMAPHY (Structural preferences of histone variants during chromatin assembly in Physarum polycephalum.)
ChromaPhy's research focused on mechanisms of epigenetic inheritance. By combining novel techniques in chemical biology and live-cell imaging, we have developed a novel method to incorporate synthetic histones into chromatin. We have pioneered the use of the organism Physarum polycephalum as a model for studying this incorporation. This research has led to the development of novel reagents that can be used to probe components of the chromatin assembly pathway. Our detailed results will be disseminated as a peer-reviewed publication in the research literature, and the novel reagents are immediately available on request to interested researchers.