Objective
Signaling via platelet surface receptors is essential for maintaining hemostasis and thrombosis, and plays key roles in pathophysiological processes related to development, immune responses and cancer. Despite their vital roles, important aspects of their regulation mechanisms remain unknown due to inherent flexibility and multilayered activation. I propose to embark upon a new approach to investigate the dynamical processes by which platelet receptors are regulated using a combination of x-ray crystallography, electron microscopy, biochemistry, bioinformatics and small-molecule design. My goal is to decipher the atomic mechanistic details of the relationship between ligand-binding, dynamics, activation and transduction of signals in platelet receptors, which would facilitate the development of accurate interventions with their cellular processes, namely drugs that will target a range of cardiovascular conditions. My working hypothesis is that small molecules that act as allosteric regulators can uncover new principles in the regulation mechanisms of these receptors, and can intervene in protein function and nucleate drug discovery efforts. Accordingly, I aim to identify and characterize small molecules that target allosteric sites in these signaling receptors, which are expressed on cell surfaces and bind ligands in the extracellular matrix, making them particularly accessible to exogenous modulation in-vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.