Objetivo Signaling via platelet surface receptors is essential for maintaining hemostasis and thrombosis, and plays key roles in pathophysiological processes related to development, immune responses and cancer. Despite their vital roles, important aspects of their regulation mechanisms remain unknown due to inherent flexibility and multilayered activation. I propose to embark upon a new approach to investigate the dynamical processes by which platelet receptors are regulated using a combination of x-ray crystallography, electron microscopy, biochemistry, bioinformatics and small-molecule design. My goal is to decipher the atomic mechanistic details of the relationship between ligand-binding, dynamics, activation and transduction of signals in platelet receptors, which would facilitate the development of accurate interventions with their cellular processes, namely drugs that will target a range of cardiovascular conditions. My working hypothesis is that small molecules that act as allosteric regulators can uncover new principles in the regulation mechanisms of these receptors, and can intervene in protein function and nucleate drug discovery efforts. Accordingly, I aim to identify and characterize small molecules that target allosteric sites in these signaling receptors, which are expressed on cell surfaces and bind ligands in the extracellular matrix, making them particularly accessible to exogenous modulation in-vivo. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicineangiologyvascular diseasesnatural sciencesearth and related environmental sciencesgeologymineralogycrystallographymedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineoncology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Convocatoria de propuestas FP7-PEOPLE-2012-CIG Consulte otros proyectos de esta convocatoria Régimen de financiación MC-CIG - Support for training and career development of researcher (CIG) Coordinador TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Aportación de la UE € 100 000,00 Dirección SENATE BUILDING TECHNION CITY 32000 Haifa Israel Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Mark Davison (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
