Objectif It is unquestioned that early detection of cancer is a major factor contributing to therapy outcome. Unfortunately, onlyfew tumour markers have been identified for early stage cancers to date, and the reliable detection of tumours before the manifestation of morphological changes still remains an unresolved problem in routine clinical diagnosis. A recent study came to the conclusion that shedding rates of currently available cancer biomarkers are a factor of 10-4 below the necessary sensitivity to reliably detect cancers during their first decade. In other studies, the reliability of currently existing biomarkers such as the PSA-marker for prostate cancer is questioned. The development of alternative early-stage tumour markers, in particular also for epithelial cancers, is therefore urgently necessary.FLOWERFIELDS is aimed to provide means and methods to detect such cancer cells before an aggressive tumour isformed. To that end, we plan to exploit the extracellular molecular code called “The Flower Code” (Fwe) that is expressed in very early stage cancer or precancerous cells. Fwe may be integrated into routine immuno- or PCR-assays for the detection of a variety of epithelial cancers. Applications may include early-stage diagnosis but also the evaluation of therapy outcome.The current project has two aims: (i) to develop improved ligands for ELISA diagnostic tests for Flower gene expression, (ii) to validate the concept clinically on human samples in both immuno- and PCR-based assays. The clinical validation of a biomarker candidate is a key success factor for being able to feed it into development stage of a commercial partner. Champ scientifique medical and health sciencesclinical medicineoncologyprostate cancernatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-OA-2012-PoC - European Research Council ERC Proof of Concept Appel à propositions ERC-2012-PoC Voir d’autres projets de cet appel Régime de financement CSA-SA(POC) - Supporting action (Proof of Concept) Institution d’accueil UNIVERSITAET BERN Contribution de l’UE € 138 030,00 Adresse HOCHSCHULSTRASSE 6 3012 Bern Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Type d’activité Higher or Secondary Education Establishments Contact administratif Maddalena Tognola (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITAET BERN Suisse Contribution de l’UE € 138 030,00 Adresse HOCHSCHULSTRASSE 6 3012 Bern Voir sur la carte Région Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Type d’activité Higher or Secondary Education Establishments Contact administratif Maddalena Tognola (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
