Skip to main content
Ir a la página de inicio de la Comisión Europea (se abrirá en una nueva ventana)
español es
CORDIS - Resultados de investigaciones de la UE
CORDIS
Contenido archivado el 2024-05-29

Sulfolobus, a model archaeon for studying the orgin of eukaryotes and development of their information processing systems

Objetivo

The evolution of Life on Earth has resulted in three types of organisms: the eukaryotes (higher organisms) and two distinct types of prokaryotes: the bacteria and the more recently discovered archaea. The archaea constitute a crucial link in the evolution of the prokaryotic to the aukaryotic cell. The essential systems for the processing of genetic information (DNA>RNA>Protein) that are present in eukaryotes are very similar to their simpler counterparts in archaea, and differ substantially form those in bacteria. Hence, archaea are excellent model systems for studying replication, DNA repair, transcription and translation in higher organisms. The model archaeon Sulfolobus is a unique candidate for an integrated multi-disciplinary project. The proposed SOLAR project will generate new insight on the processing of genetic information, by (i) extending the set of key proteins (and non coding-RNAs) involved and elucidating their interactions in vivo and in vitro, (ii) unravelling novel molecular mechanisms, and (iii) determining the modes of regulation of the protein complexes involved. This will certainly provide fundamental insights into the evolution of these importent processes, and into the orgin of the eukaryotic cell. Moreover, since malfunctions of the information processing systems, or their control, can have a major impact on survival and proliferation of cells and organisms, SOLAR applicants have recently filed several patents on new findings about archaeal protein functions that can lead to improved diagnosis and treatment of human diseases including cancer; the SOLAR project is anticipated to further extend these very promising developments. The partners of the SOLAR consortium have been selected on the basis of both excellent track records and complementary expertise. As such, the proposed project provides a unique opportunity for training of young, talented, European scientists in cutting-edge post-genomic and biochemical technologies.

Ámbito científico (EuroSciVoc)

Palabras clave

Tema(s)

Convocatoria de propuestas

FP6-2005-MOBILITY-1
Consulte otros proyectos de esta convocatoria

Régimen de financiación

RTN - Marie Curie actions-Research Training Networks

Coordinador

WAGENINGEN UNIVERSITEIT
Aportación de la UE
Sin datos
Coste total
Sin datos

Participantes (8)