Objetivo The maintenance of the skeleton is tightly coupled with balanced bone formation and resorption processes that are mediated by osteoblasts and osteoclasts, respectively. Loss of this balance results in skeletal pathologies representing some of the most significant public health threats faced by the growing and ageing population. Tissue engineering investigates various health aspects such as drug development, fundamental research and regenerative medicine. State-of-the-art approaches are lacking to mimic one essential functional property of bone: to adapt its 3D morphology according to imposed mechanical loads. As most drugs for skeletal diseases act on this anabolic-catabolic balance, an engineered system serving as a human in vitro model for drug discovery/testing needs to be able to mimic this process. This proposal aims at combining real-time monitoring of mineralized extracellular matrix with bone tissue engineering culture standards in advanced bioreactors and will design a reliable 3D in vitro model system to mimic load induced remodeling of tissue-engineered human bone. The following particulars will be systematically addressed: i) Establishment of a co-culture of human bone-forming cells and human bone resorbing cells capable of mimicking bone remodeling; ii) Real-time monitoring platform in 3D in order to take the temporo-spatial development of the tissue into account and to allow specific adapted and controlled interventions depending on the actual environmental situation; iii) Quantitative simulation of morphological bone adaptation induced by mechanical load. The proposed research activity will have important implications in fields ranging from pharmacology and biotechnology to biomechanics and medicine. It will result in a ground-breaking platform that could be applied to screen initial bone drug effects and will improve our fundamental understanding of structure-function relationships in normal and diseased bone conditions. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencespublic healthepidemiologyepidemics preventionmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesbiophysics Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-PE8 - ERC Starting Grant - Products and process engineering Convocatoria de propuestas ERC-2013-StG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida TECHNISCHE UNIVERSITEIT EINDHOVEN Aportación de la UE € 1 496 859,00 Dirección GROENE LOPER 3 5612 AE Eindhoven Países Bajos Ver en el mapa Región Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo J.M.R. Debeij (Mr.) Investigador principal Sandra Hofmann Boss (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo TECHNISCHE UNIVERSITEIT EINDHOVEN Países Bajos Aportación de la UE € 1 496 859,00 Dirección GROENE LOPER 3 5612 AE Eindhoven Ver en el mapa Región Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo J.M.R. Debeij (Mr.) Investigador principal Sandra Hofmann Boss (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos