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Harnessing Cavitation for Therapy

Objective

Focused Ultrasound Surgery (FUS) is rapidly emerging as a technique setting the gold-standard for the treatment of a wide range of diseases, including cancer. Current practise relies on the conversion of acoustic energy to thermal, for localised and minimally-invasive ablation with non-ionising radiation. Cavitation (the formation, and subsequent pressure driven dynamics, of bubbles) is a common occurrence at the high intensities typically employed for FUS. The extremely rapid, often violent evolution of cavitation in tissue exposed to focused ultrasound, poses a high risk of collateral damage to healthy tissue proximal to the site of pathology. TheraCav will demonstrate cavitation can be controlled and harnessed, to redefine the remit of FUS to include targeted drug delivery and rapid ablation formation via enhanced heating. Conceptually, cavitation could act to significantly permeabilise targeted tissue, rendering specific volumes highly susceptible to drug delivery through extravasation from the vasculature. Moreover, cavitation may actively pump and promote drug transport directly to the diseased tissue. If cavitation is to fulfil this potential, however, it is crucial that precise monitoring and control strategies are developed, demonstrating that it can be safely introduced and utilised tissue. Through a series of novel and ambitious objectives, TheraCav will develop techniques and devices to deliver this capability, calibrated against a recent innovation that has allowed the direct observation of cavitation at unprecedented spatial and temporal resolution. A series of translational work packages will test the monitoring and control strategies developed, in tissue-mimicking materials and ultimately soft-embalmed cadaver models, for anatomical verification.
Finally, a radical and highly ambitious objective of activating photodynamic therapy drug compounds, via cavitation sonoluminescence and reactive oxygen species production, will be investigated.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /medical and health sciences/clinical medicine/surgery
  • /natural sciences/physical sciences/acoustics/ultrasound
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /social sciences/social and economic geography/transport

Call for proposal

ERC-2013-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

UNIVERSITY OF GLASGOW
Address
University Avenue
G12 8QQ Glasgow
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 888 284,55
Principal investigator
Paul Alan Prentice (Mr.)
Administrative Contact
Joe Galloway (Mr.)

Beneficiaries (2)

UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 888 284,55
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Principal investigator
Paul Alan Prentice (Mr.)
Administrative Contact
Joe Galloway (Mr.)
UNIVERSITY OF DUNDEE

Participation ended

United Kingdom
EU contribution
€ 564 895,45
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Diane Taylor (Ms.)