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Enzymology of oxidative sulfur transfers

Objective

Oxidative stress causes cancer, cardiovascular, neurodegenerative and infective disease. Much of cellular oxidative stress is mediated, communicated, mitigated or amplified by a complex system of sulphur containing small metabolites or protein based cysteines. Characterization of key players and reactions in this network is crucial for preventive and therapeutic interventions.
I propose a new perspective on sulphur biochemistry. The reactivity of sulphur with the oxidative stressors superoxide, peroxides or hydroxyl radicals is well established, but far less is known about reactions between sulphur and molecular oxygen. I shall demonstrate that this reaction is fundamental to cellular life, and how advances in this field provide new options in medicine, biotechnology and the food industry.
Assisted by a team of three PhD students and a postdoctoral researcher I intend to establish this new research field by identification, characterization and engineering of enzymatic activities which catalyse oxidative carbon-sulfur bond formation and cleavage. Specific systems in this study include the biosynthetic enzymes for ergothioneine, sparsomycine and alliin, all of which are sulphur containing secondary metabolites with potent activities on cellular functions.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /natural sciences/biological sciences/biochemistry
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

ERC-2013-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

UNIVERSITAT BASEL
Address
Petersplatz 1
4051 Basel
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 497 201,60
Principal investigator
Florian Peter Seebeck (Prof.)
Administrative Contact
Kurt Kamber (Dr.)

Beneficiaries (1)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 1 497 201,60
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Principal investigator
Florian Peter Seebeck (Prof.)
Administrative Contact
Kurt Kamber (Dr.)