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Vascular remodelling and miRNA therapeutics

Objective

The central hypothesis of VascmiR is that microRNAs (miRs) fundamentally control pathological remodelling of the vasculature. The complexity of vascular bed heterogeneity and subsequent response to injury, the potential importance of miRNA in vascular pathology and the paucity in knowledge relating to many facets of miRNA function in the vessel wall including target pathways, mechanistic features of miRNA-mediated cell:cell communication mediated by miRNA export and uptake etc. provides an excellent opportunity for groundbreaking basic and translational research in the field. VascmiR will envelop these concepts in a broad, cutting edge portfolio of high risk and in-depth studies that encompass fundamental research, mouse genetics to create novel models and miR intervention studies in small and large animal models coupled with targeted miRNA therapeutics. Collective synergy by assessing pulmonary as well as peripheral venous and arterial pathological vascular remodelling models of disease under a single funding mechanism will afford substantial scientific advancement. VascmiR will go beyond current state-of-the-art and create new knowledge of miRNA in vascular pathologies, all of which have important unmet clinical need. VascmiR will streamline fundamental new opportunities for targeted miRNA-based therapeutics to improve human health in cardiovascular setting. I envisage that a co-ordinated, multifaceted and integrative programme in these vascular pathology settings to better understand the mechanistic role of miRNA in vascular remodelling will have a major impact on the field, leading to early translation of advanced miRNA therapeutics in the vasculature.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /natural sciences/biological sciences/genetics and heredity

Call for proposal

ERC-2013-ADG
See other projects for this call

Funding Scheme

ERC-AG - ERC Advanced Grant

Host institution

THE UNIVERSITY OF EDINBURGH
Address
Old College, South Bridge
EH8 9YL Edinburgh
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 914 506,40
Principal investigator
Andrew Baker (Prof.)
Administrative Contact
Alan Kennedy (Mr.)

Beneficiaries (2)

THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 914 506,40
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Principal investigator
Andrew Baker (Prof.)
Administrative Contact
Alan Kennedy (Mr.)
UNIVERSITY OF GLASGOW

Participation ended

United Kingdom
EU contribution
€ 580 437,60
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)