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Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease: the PREDIMED PLUS Study

Objetivo

The impact of weight loss on cardiovascular disease risk within the frame of the Mediterranean dietary pattern has not yet been tested using a sufficiently large randomized trial (Malik, Hu, 2007). We propose to run a parallel group, multi-center, randomized, primary prevention trial (PREDIMED PLUS) on men aged 55-75 years and women 65-75 years, with a body mass index ≥27 to <40 kg/m2 and meeting at least 3 criteria for the metabolic syndrome. The objective of the present research is to address the cardiovascular effect of an intensive weight-loss lifestyle intervention based on an energy-restricted traditional Mediterranean diet in comparison with a less intensive program using Mediterranean diet, but with no energy restriction, behavioural intervention or physical activity programme. The end-point is a composite of major hard clinical cardiovascular events. We hypothesize that an intensive weight-loss lifestyle intervention, including physical activity, based on the traditional Mediterranean food pattern is a sustainable long-term approach for weight reduction among overweight/obese adults and that the achieved lifestyle changes will exert beneficial effects on cardiovascular disease incidence, according to our experience (Estruch R et al., 2012) and research by other investigators (Shai et al., 2008). The rationale for the proposed investigation is that it can provide a new, affordable, and sustainable approach to reduce excess cardiovascular morbidity and mortality among overweight/obese adults, beyond what was already observed in the PREDIMED I trial.

Ámbito científico

  • /ciencias sociales/economía y empresa/ciencia económica/economía sostenible
  • /ciencias sociales/sociología/demografía/mortalidad

Convocatoria de propuestas

ERC-2013-ADG
Consulte otros proyectos de esta convocatoria

Régimen de financiación

ERC-AG - ERC Advanced Grant

Institución de acogida

UNIVERSIDAD DE NAVARRA
Dirección
Campus Universitario Edificio Central
31080 Pamplona
España
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 496 754,47
Investigador principal
Miguel ángel Martínez González (Prof.)
Contacto administrativo
Fco. Javier Irigoyen Barrio (Mr.)

Beneficiarios (2)

UNIVERSIDAD DE NAVARRA
España
Aportación de la UE
€ 1 496 754,47
Dirección
Campus Universitario Edificio Central
31080 Pamplona
Tipo de actividad
Higher or Secondary Education Establishments
Investigador principal
Miguel ángel Martínez González (Prof.)
Contacto administrativo
Fco. Javier Irigoyen Barrio (Mr.)
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
España
Aportación de la UE
€ 582 215,15
Dirección
Calle Monforte De Lemos 5
28029 Madrid
Tipo de actividad
Research Organisations
Contacto administrativo
Manuel Sanchez (Mr.)