Obiettivo The impact of weight loss on cardiovascular disease risk within the frame of the Mediterranean dietary pattern has not yet been tested using a sufficiently large randomized trial (Malik, Hu, 2007). We propose to run a parallel group, multi-center, randomized, primary prevention trial (PREDIMED PLUS) on men aged 55-75 years and women 65-75 years, with a body mass index ≥27 to <40 kg/m2 and meeting at least 3 criteria for the metabolic syndrome. The objective of the present research is to address the cardiovascular effect of an intensive weight-loss lifestyle intervention based on an energy-restricted traditional Mediterranean diet in comparison with a less intensive program using Mediterranean diet, but with no energy restriction, behavioural intervention or physical activity programme. The end-point is a composite of major hard clinical cardiovascular events. We hypothesize that an intensive weight-loss lifestyle intervention, including physical activity, based on the traditional Mediterranean food pattern is a sustainable long-term approach for weight reduction among overweight/obese adults and that the achieved lifestyle changes will exert beneficial effects on cardiovascular disease incidence, according to our experience (Estruch R et al., 2012) and research by other investigators (Shai et al., 2008). The rationale for the proposed investigation is that it can provide a new, affordable, and sustainable approach to reduce excess cardiovascular morbidity and mortality among overweight/obese adults, beyond what was already observed in the PREDIMED I trial. Campo scientifico scienze socialisociologiademografiamortalitàingegneria e tecnologiaingegneria dei materialicompositiscienze mediche e della salutescienze della salutenutrizionescienze mediche e della salutemedicina clinicacardiologiamalattie cardiovascolari Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Invito a presentare proposte ERC-2013-ADG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Coordinatore UNIVERSIDAD DE NAVARRA Indirizzo Campus universitario edificio central 31080 Pamplona Spagna Mostra sulla mappa Regione Noreste Comunidad Foral de Navarra Navarra Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Miguel ángel Martínez González (Prof.) Contatto amministrativo Fco. Javier Irigoyen Barrio (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE € 1 496 754,47 Beneficiari (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSIDAD DE NAVARRA Spagna Contributo UE € 1 496 754,47 Indirizzo Campus universitario edificio central 31080 Pamplona Mostra sulla mappa Regione Noreste Comunidad Foral de Navarra Navarra Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Miguel ángel Martínez González (Prof.) Contatto amministrativo Fco. Javier Irigoyen Barrio (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. Spagna Contributo UE € 582 215,15 Indirizzo Calle monforte de lemos 5 28029 Madrid Mostra sulla mappa Regione Comunidad de Madrid Comunidad de Madrid Madrid Tipo di attività Research Organisations Contatto amministrativo Manuel Sanchez (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window
