Objective
Cancer of the non-medullary (follicular epithelium) component of the thyroid is induced by external irradiation and by radionuclides deposited within the thyroid tissues. Estimates of the radiological risk of developing thyroid cancer are derived from epidemiological studies performed in populations receiving high doses. Extrapolation of this risk to exposures at much lower doses is compromised by the lack of an accurate model of the dose response curve for thyroid cancer at low doses. Moreover, such population-based estimates fail to take into account the contribution of individual genetic variability to the risk estimate. Individuals with an increased genetic predisposition to develop thyroid cancer are not identified, and it is precisely these individuals who will be at greatest risk at low doses. The GENRISK-T consortium is composed of thyroid cancer experts with experience in the fields of radiation biology, animal models of radiation-induced cancer, tumour banking, cancer biology, molecular genetics, histopathology, cytogenetics and risk modelling. We will use this interdisciplinary knowledge to define the genetic component influencing the risk of radiation-induced thyroid cancer. This will be achieved through a combination of studies using animal models and in human radiation-induced thyroid tumours. This new understanding of genetic risk modifiers will be used to develop an animal model of thyroid cancer that is responsive to low dose radiation in the cGy range, thereby providing an experimental solution to resolving the uncertainties of the low dose response curve.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences molecular biology molecular genetics
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences nuclear chemistry radiation chemistry
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
EURATOM-2005-6-FIXEDDEADLINE
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NEUHERBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.