Objective Cancer of the non-medullary (follicular epithelium) component of the thyroid is induced by external irradiation and by radionuclides deposited within the thyroid tissues. Estimates of the radiological risk of developing thyroid cancer are derived from epidemiological studies performed in populations receiving high doses. Extrapolation of this risk to exposures at much lower doses is compromised by the lack of an accurate model of the dose response curve for thyroid cancer at low doses. Moreover, such population-based estimates fail to take into account the contribution of individual genetic variability to the risk estimate. Individuals with an increased genetic predisposition to develop thyroid cancer are not identified, and it is precisely these individuals who will be at greatest risk at low doses. The GENRISK-T consortium is composed of thyroid cancer experts with experience in the fields of radiation biology, animal models of radiation-induced cancer, tumour banking, cancer biology, molecular genetics, histopathology, cytogenetics and risk modelling. We will use this interdisciplinary knowledge to define the genetic component influencing the risk of radiation-induced thyroid cancer. This will be achieved through a combination of studies using animal models and in human radiation-induced thyroid tumours. This new understanding of genetic risk modifiers will be used to develop an animal model of thyroid cancer that is responsive to low dose radiation in the cGy range, thereby providing an experimental solution to resolving the uncertainties of the low dose response curve. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmolecular biologymolecular geneticsmedical and health sciencesclinical medicineoncologynatural scienceschemical sciencesnuclear chemistryradiation chemistry Programme(s) FP6-EURATOM-RADPROT - Thematic priority - Radiation Protection as part of the specific framework programme for the European Atomic Energy Community, within the multi-annual framework programme 2002-2006. Topic(s) RAD PROT-2005/6-3.3.1.1-2 - Cellular and molecular biology research on the effects of low and protracted doses Call for proposal EURATOM-2005-6-FIXEDDEADLINE See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Address Ingolstaedter landstrasse 1 Neuherberg Germany See on map Links Website Opens in new window EU contribution € 0,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L'ENERGIE ATOMIQUE (CEA) France EU contribution € 0,00 Address Batiment le ponant d - 25 rue leblanc Paris See on map Links Website Opens in new window UNIVERSITY OF WALES SWANSEA GB EU contribution € 0,00 Address Singleton park Swansea See on map IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE GB EU contribution € 0,00 Address Exhibition road London See on map Links Website Opens in new window MARIA SKLODOWSKA-CURIE MEMORIAL CANCER CENTER Poland EU contribution € 0,00 Address Roentgena 5 Warzawa w.k. See on map Links Website Opens in new window UNIVERSITE LIBRE DE BRUXELLES Belgium EU contribution € 0,00 Address Avenue franklin roosevelt 50 Brussels See on map Links Website Opens in new window UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II. Italy EU contribution € 0,00 Address Corso umberto i, 40 Napoli See on map Links Website Opens in new window STUDIECENTRUM VOOR KERNENERGIE - CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE Belgium EU contribution € 0,00 Address Avenue hermann-debroux 40 Brussels See on map Links Website Opens in new window CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT Spain EU contribution € 0,00 Address Av. comlutense 22 Madrid See on map Links Website Opens in new window ASCENION GMBH Germany EU contribution € 0,00 Address Herzogstrasse 68 Munich See on map Links Website Opens in new window
