Objective
VALAPODYN seeks to advance the development of multidisciplinary functional genomics relating to complex biological processes & cellular networks. The project concerns both DNA & protein applications, followed by innovative dynamic modelling of pathological disease states such as epilepsy, cancer in order to validate the model. The overall aim is to develop an innovative System Biology approach in order to model the dynamics of Molecular Interaction Networks (MIN) related to cell death & survival in the organism. The future dynamic model will be dedicated to selection of drug targets designed to treat human pathologies such as epilepsy, cancer, neurodegenerative diseases. The overall result of dynamic modelling will be an immediate selection of the most efficient putative therapeutic targets, decreasing by at least 10 times the number to study & thus increasing cost effectiveness. S&T objectives are: Pathways analysis: functional annotation of genes & proteins, investigation of structure & dynamics of signal transduction & transcription regulatory networks.; Predictive bioinformatics platform for dynamic modelling: to use innovative biomathematics/bioinformatics to integrate experimental MIN data with biological tissue & pathological states data obtained through the use of transcriptomic & proteomic approaches.; Bioinformatics: to set up a highly specialised database on genomics & proteomics of MIN modelling.; Pathological tissue & animal models: to use novel animal models to evaluate local expression genes/proteins in neurodegenerescence.; Microarrays: to set up a network of microarrays using the Codelink platform.; Proteomics: to form a network of advanced quantitative methods in proteomics technologies (MALDI, ICAT, 2-DPAGE, Heavy Peptides isotopic dilution).; Neuroprotective molecules: to characterise molecules (or combination of molecules) in the MIN of neurodegeneration (NDG) which will have an effect in stopping or curing NDG...
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology epilepsy
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.