Objective
Epilepsies are chronic disorders with a prevalence of 1% worldwide including Europe; they severely affect the quality of life of patients, especially of those (one third) who are drug-resistant. They are multifactorial disorders sharing common pathophysiological mechanisms among which dysfunctions in voltage-gated and ligand-gated (receptors) ion channels and alterations in structure and function of neuronal networks play a major role. This project will identify disease-causing genes and their functional role in the pathophysiology of neuronal excitability and network synchronization, using complementary advanced methods. The work will be focused on voltage-gated Na+ channels and GABAergic synaptic inhibition. Their crucial epileptogenic role is recognized for both inherited acquired epilepsies and will be investigated in animal models and human tissue with a focus on drug resistant temporal lobe epilepsy and epilepsies due to developmental cortical abnormalities. A main effort is devoted to investigate developmental aspects of epileptogenesis that account for the high frequency of epilepsies in children and for their often severe prognosis.
Strictly related to the above research lines are the pharmacological approaches by which EPICURE aims at developing more effective antiepileptic strategies, at understanding the biological bases of pharmacoresistance and at evaluating the potential of innovative therapeutic approaches based on synaptic modulation by neurotrophic factors and cell cycle kinase inhibitors. Despite the internationally recognized role of epilepsy research in Europe, the leading research groups lack a central coordination to take advantage of cross-fertilization and synergistic effects. EPICURE intends to bring together expertise from different research areas both clinical and laboratory-based with the common goal of advancing European epilepsy research to bring about novel therapeutic benefits to patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MILANO
Italy
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Participants (32)
PARIS
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VERONA
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ERLANGEN
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BUDAPEST
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BONN
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BERLIN
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117 LUND
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85600 UTRECHT
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HELSINKI
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ULM
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MAINZ
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ISTANBUL
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PAVIA
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1627 KUOPIO
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MARBURG
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MADRID
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FERRARA
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INNSBRUCK
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LONDON
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MILANO
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GENOVA
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MARSEILLE
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ISTANBUL
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BALLERUP
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MARSEILLE
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DUBLIN
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MILANO
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FIRENZE
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COLOGNE
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GENTILLY
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TUEBINGEN
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MAINZ
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