Objective
Translational research of childhood tumours to identify molecular targets for novel generation drugs is urgently needed. Nine European research centres devoted to molecular-biology and pharmacology studies of childhood cancers and two SMEs therefore engaged in the KidsCancer Kinome project. KidsCancer Kinome will make a comprehensive analysis of the human protein kinase family. Protein kinases are already excellent targets for many small inhibitory molecules and antibodies designed for adult tumours. Six aggressive childhood tumours (neuroblastoma, medulloblastoma, rhabdomyosarcoma, osteosarcoma, Ewing' tumour and acute lymphocytic leukaemia) will be addressed. These six tumours are responsible for 50% of childhood cancer deaths. Viral shRNA libraries will be applied to test the entire human kinase gene family for tumour-driving kinases in cell lines. They will subsequently be analyzed for mutations and functional parameters in large cohorts of tumour samples. siRNA mediated inactivation in larger cell line panels will critically validate suitable kinases as drug targets. Novel kinase inhibitors being developed for adult oncology will be tested for in vitro activity against the tumour-driving kinases. When no inhibitor is available, a novel generation of siRNA based nucleic acid drugs (LNAs) will be applied. Successful compounds will be taken further to in vivo validation in established xenograft models of the six childhood tumour types. KidsCancer Kinome will tribute to a better understanding of the unique paediatric tumour biology and to the development of new drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology leukemia
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VILLEJUIF
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.