Objectif The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to determine gene expression profiles specific for genetic and idiopathic Parkinson's disease (PD) patients. These gene expression signatures will be utilised clinically as non-invasive diagnostic tests for PD. The sensitivity of the newly developed diagnostic test will be determined by extensive validations on independent cohort of PD patients, whereas the specificity will be assessed by testing patients with atypical parkinsonisms, including multiple system atrophy, progressive supranuclear palsy and diffuse Lewy body disease. In order to test the specificity of the diagnostic set in other disorders that affect basal ganglia, Huntington's disease and dopa responsive dystonia patients will be analysed. The second objective of the proposal is to determine correlations between gene expression signatures and different stages of PD and thus provide the basis for early diagnosis and monitoring of disease progression. These changes in blood gene expression will be correlated with alterations detected by neuroimaging in the brain of PD patients. Such combinations of molecular and morphological markers of disease may ultimately facilitate the selection and monitoring of neuroprotective therapies for PD. Finally, GENEPARK aims to develop new bioinformatic software tools for selection of genomic biomarkers using microarray data. A set of established computational tools will be applied and novel methods, some of them based on mechanistic modelling of the neurodegenerative diseases, will be developed in order to study the advantages and limitations of the different methodologies. With special emphasis on careful clinical selection of patients and sufficient power regarding patient numbers, as well as extensive quality control and validation of the data, GENEPARK aims to develop a standardised approach to development and validation of haemogenomic biomarkers of disease. Champ scientifique natural sciencesbiological sciencesgeneticsnatural sciencescomputer and information sciencessoftwaremedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2005-1.2.2-2 - Development of innovative methods for diagnosis of nervous system disorders Appel à propositions FP6-2005-LIFESCIHEALTH-6 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur UNIVERSITY MEDICAL CENTER LJUBLJANA Contribution de l’UE Aucune donnée Adresse Zaloska cesta 2 LJUBLJANA Slovénie Voir sur la carte Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF LUEBECK Allemagne Contribution de l’UE Aucune donnée Adresse Ratzeburger Allee 160 LUEBECK Voir sur la carte Coût total Aucune donnée MEDITERANEAN INSTITUTE FOR LIFE SCIENCES Croatie Contribution de l’UE Aucune donnée Adresse Mestrovicevo setaliste bb SPLIT Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée PROGENIKA BIOPHARMA S.A. Espagne Contribution de l’UE Aucune donnée Adresse Parque Tecnologico Zamudio, 801-B DERIO Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée EBERHARD-KARLS-UNIVERSITY TUEBINGEN Allemagne Contribution de l’UE Aucune donnée Adresse Wilhelmstr. 5 TUEBINGEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée TEL AVIV UNIVERSITY Israël Contribution de l’UE Aucune donnée Adresse Ramat Aviv 39040 TEL AVIV Voir sur la carte Coût total Aucune donnée RR & CO. PODJETJE ZA POSLOVNE STORITVE, D.O.O. Slovénie Contribution de l’UE Aucune donnée Adresse Dunajska cesta 20 LJUBLJANA Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Contribution de l’UE Aucune donnée Adresse 101 rue de Tolbiac PARIS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée