Obiettivo The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to determine gene expression profiles specific for genetic and idiopathic Parkinson's disease (PD) patients. These gene expression signatures will be utilised clinically as non-invasive diagnostic tests for PD. The sensitivity of the newly developed diagnostic test will be determined by extensive validations on independent cohort of PD patients, whereas the specificity will be assessed by testing patients with atypical parkinsonisms, including multiple system atrophy, progressive supranuclear palsy and diffuse Lewy body disease. In order to test the specificity of the diagnostic set in other disorders that affect basal ganglia, Huntington's disease and dopa responsive dystonia patients will be analysed. The second objective of the proposal is to determine correlations between gene expression signatures and different stages of PD and thus provide the basis for early diagnosis and monitoring of disease progression. These changes in blood gene expression will be correlated with alterations detected by neuroimaging in the brain of PD patients. Such combinations of molecular and morphological markers of disease may ultimately facilitate the selection and monitoring of neuroprotective therapies for PD. Finally, GENEPARK aims to develop new bioinformatic software tools for selection of genomic biomarkers using microarray data. A set of established computational tools will be applied and novel methods, some of them based on mechanistic modelling of the neurodegenerative diseases, will be developed in order to study the advantages and limitations of the different methodologies. With special emphasis on careful clinical selection of patients and sufficient power regarding patient numbers, as well as extensive quality control and validation of the data, GENEPARK aims to develop a standardised approach to development and validation of haemogenomic biomarkers of disease. Campo scientifico natural sciencesbiological sciencesgeneticsnatural sciencescomputer and information sciencessoftwaremedical and health sciencesbasic medicineneurologyparkinson Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2005-1.2.2-2 - Development of innovative methods for diagnosis of nervous system disorders Invito a presentare proposte FP6-2005-LIFESCIHEALTH-6 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITY MEDICAL CENTER LJUBLJANA Contributo UE Nessun dato Indirizzo Zaloska cesta 2 LJUBLJANA Slovenia Mostra sulla mappa Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF LUEBECK Germania Contributo UE Nessun dato Indirizzo Ratzeburger Allee 160 LUEBECK Mostra sulla mappa Costo totale Nessun dato MEDITERANEAN INSTITUTE FOR LIFE SCIENCES Croazia Contributo UE Nessun dato Indirizzo Mestrovicevo setaliste bb SPLIT Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato PROGENIKA BIOPHARMA S.A. Spagna Contributo UE Nessun dato Indirizzo Parque Tecnologico Zamudio, 801-B DERIO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato EBERHARD-KARLS-UNIVERSITY TUEBINGEN Germania Contributo UE Nessun dato Indirizzo Wilhelmstr. 5 TUEBINGEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato TEL AVIV UNIVERSITY Israele Contributo UE Nessun dato Indirizzo Ramat Aviv 39040 TEL AVIV Mostra sulla mappa Costo totale Nessun dato RR & CO. PODJETJE ZA POSLOVNE STORITVE, D.O.O. Slovenia Contributo UE Nessun dato Indirizzo Dunajska cesta 20 LJUBLJANA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo 101 rue de Tolbiac PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato