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Optimisation of protein crystallisation for European structural genomics

Objectif

The OptiCryst STREP aims to take a leap forward scientifically and commercially to obtain high-quality crystals of proteins which are proving difficult to crystallise, providing a support platform for Europe's Structural Genomics initiatives that are struggling to deliver structures. Protein crystallisation has gained a new strategic and commercial relevance in the post-genomic era due to its pivotal role in Structural Genomics: producing high-quality crystals has always been a bottleneck to structure determination and this problem is becoming increasingly acute within worldwide initiatives.
This is especially true for challenging therapeutically important proteins that typically do not form suitable crystals. It is clear that the only way to relieve the bottleneck of crystallisation is to focus a concerted effort on the science that underlies it. Research advances in recent years have opened up the scope for development and commercialisation of new tools and methods to adopt this relatively unexplored approach. 7 research-intensive SMEs' from 5 European countries (holding 54.4% of the total budget) and 4 research institutions' scientific expertise will reinforce technological knowledge and the validation of innovative solutions. The SMEs play leading roles and one is the coordinator. Opticryst will capitalise on this momentum and prevent difficult proteins from being consigned to Structural Genomics's 'back burner'.
Opticryst has 2 key objectives: Develop and commercialise new, improved methods and equipment to obtain high-quality crystals of proteins difficult to crystallise; develop a platform for supporting the Structural Genomics initiatives in Europe struggling to deliver the number of structures that was hoped for. In conclusion, OptiCryst is designed to establish a new state-of-the-art in protein crystallisation. Our consortium of commercial and academic partners will give Europe a leading role in an area crucial to improving human health and the economy.'

Appel à propositions

FP6-2005-LIFESCIHEALTH-7
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Coordinateur

ASTON UNIVERSITY
Adresse
Aston Triangle
Birmingham
United Kingdom

Participants (11)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Espagne
Adresse
C/ Serrano 117
Madrid
DOUGLAS INSTRUMENTS LTD
United Kingdom
Adresse
Douglas House, East Garston
Hungerford
FARFIELD GROUP LIMITED (FORMERLY FARFIELD SENSORS LIMITED)
United Kingdom
Adresse
Farfield House, Southmere Court, Electra Way
Crewe
GOTHIA YEAST SOLUTIONS AB
Suède
Adresse
Terrassgatan 7
Goteborg
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Adresse
Exhibition Road, South Kensington Campus
London
KEY DRUG PROTOTYPING BV
Pays-Bas
Adresse
Kruislaan 406
Amsterdam
MOLECULAR DIMENSIONS LTD
United Kingdom
Adresse
Unit 4 Northfield Business Park, Northfield Road
Soham
PLS DESIGN GMBH
Allemagne
Adresse
Eichenstrasse 42
Hamburg
TRIANA SCIENCE & TECHNOLOGY
Espagne
Adresse
Edificio Bic Granada Avenida De La Innovacion, 1 P.t. Ciencias De La Salud
Armilla (Granada)
UNIVERSITAT HAMBURG
Allemagne
Adresse
Edmund-siemers-allee 1
Hamburg
UNIVERSITÄT ZU LÜBECK
Allemagne
Adresse
Ratzeburger Allee 160
Lubeck