Objective
Prostacyclin is a powerful endogenous mediator involved in the regulation of a number of essential biological processes.
Key functions of prostacyclin include:
(1) inhibition of platelet aggregation,
(2) vasodilatation,
(3) inhibition of vascular cell proliferation and inflammation and
(4) reduction of cholesterol accumulation.
Prostacyclin and its metabolites are clinically used to inhibit platelet aggregation (if heparin is contraindicated) and to treat pulmonary hypertension. Indeed, it is the only medication for PAH that has shown a survival benefit in a randomised clinical trial. Prostacyclin is produced by endothelial cells following the consecutive actions of cyclo-oxygenase and prostacyclin synthase. The actions of prostacyclin are mediated by two receptor classes: cell surface IP receptors, linked to adenylate cyclase, and nuclear receptor PPARbeta which regulates the transcription of several target genes to mediate cellular responses. Most recently we have shown that PPARbeta is active in platelets, which have no nucleus, suggesting that it may also have non- genomic effects.
The relative roles of IP versus PPARbeta in the sensing and signalling of prostacyclin by tissues of the cardiovascular system is not known. In the current application we seek to use selective pharmacological tools and cells from genetically modified mice (where IP or PPARbeta have been knocked-out) to firmly identify how IP and PPARbeta receptor systems act and interact when cells or platelets are treated with prostacyclin and related compounds.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences inorganic chemistry alkali metals
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.