Objective
Food allergy is a major health concern in Europe since 6 to 8% of children are suffering from it. Furthermore, the prevalence of this pathology has significantly increased during recent years. Among the foods responsible for allergy, milk is one of the most important especially in infants and young children. The proteins involved in milk allergy are the whey proteins and the caseins. During the recent years, sensitivity to casein has increased in terms of both frequency and intensity of IgE response, which is quite surprising since caseins are known to be rapidly and extensively degraded by proteolytic enzyme during digestion, limiting their allergenicity. The objective of the present project is therefore to understand why casein is a major food allergen.
Several hypotheses may explain this phenomenon and will be investigated during this project:
(1) role of casein phosphorylated sequences resistant to digestion,
(2) protection of caseins from digestion by lipids,
(3) impact of technological processes on case in digestibility.
This 3-year project will be realized thanks to a close cooperation between the Institute of Food Research (IFR) in Norwich UK (Drs Mackie and Mills) and the National Institute for Agricultural Research (INRA) in Poligny France (Dr Dupont). Most of the technical work will be done by Dr. Dupont during a one year stay at IFR where the applicant will deepen his knowledge and expertise in the food allergy area and will acquire technical skills, in particular proteomic techniques, he will need for his future scientific projects. He will use an in vitro digestion gut model previously developed at IFR that he will be able to transfer to INRA after his stay at IFR.
Finally, he will learn about EU project management, as well as networking with other centres involved in the projects IFR leads. On the other side, Dr Dupont will transfer to IFR some immunochemical techniques (ELISA, protein arrays) he has developed to follow the antigenicity of caseins.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine allergology food allergy
- natural sciences chemical sciences inorganic chemistry alkali metals
- agricultural sciences animal and dairy science dairy
- medical and health sciences basic medicine pathology
- natural sciences chemical sciences electrochemistry electrophoresis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NORWICH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.