Objective
Diabetic Nephropathy (DN) is the commonest cause of renal replacement therapy in the Western World. Hyperglycaemia and hypertension are the major determinants in the pathogenesis of DN and inflammatory mechanisms are believed to contribute to the glomerular damage. The Applicants hypothesis is that the chemokine Monocyte Chemoattractant Protein-1 (MCP-1), which is over-expressed by podocytes in experimental diabetes, plays a key role in the pathogenesis of the alterations characteristic of DN. This will be tested in vivo in diabetic animal knockout for MCP-1 and in vitro in cultured human podocytes.
The Applicant will assess in diabetic mice if the absence of MCP-1 prevents the development of proteinuria, thickening of the glomerular basement membrane, and down regulation of the podocyte protein nephrin. In vitro the Applicant will test whether podocyte exposure to high glucose and/or haemodynamic stress affects the expression of MCP-1 and its receptor CCR2. Further, if MCP-1 has direct deleterious effects in podocytes (e.g. enhanced extracellular matrix production, altered expression of proteins modulating permeability) that help explain the alterations of the diabetic glomerulus.
The Applicant has considerable expertise in vitro work, thus this part of the study will help establish her reputation in the field and reinforce her teaching abilities through supervision of younger scientists. The Applicant has no experience in in vivo/ex vivo work; thus the project will give her the opportunity to acquire new skills (e.g. animal work, tissue processing). This will broaden her area of expertise and allow her to expand her research activity beyond DN. Furthermore, it will enhance her job opportunities and her chances to submit successful research grants, and facilitate the achievement of a leadership position. The opportunity to attend advanced courses and her training in complementary skills will enhance her independence and help launch her research career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes diabetic nephropathy
- social sciences sociology demography mortality
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine nephrology kidney diseases
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TURIN
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.