Objective
Multiple Sclerosis is the chronic neurological disease the most frequent in the young adult. This disease is characterized by an inflammatory attack of the central nervous system, which leads to the destruction of the myelin gain of the axon. The animal model of this disease, the EAE (experimental autoimmune encephalomyelitis) permitted to better characterize this auto-immune disease.
More recently, the role of a specific population of lymphocytes the CD4+CD25+ regulatory T cells (Tregs) in the regulation of autoimmunity was brought to light. These cells were generated in the thymus and there is a decrease in the number and function of this class of regulatory T cells in Multiple Slerosis patients, suggesting that the loss of these cells promotes the induction and the persistence of the disease.
In EAE, there is now considerable evidence that Tregs are involved in genetic resistance and in mediating remission of the disease. Thus understanding the molecular and cellular mechanisms by which CD4+CD25+ T cells a re induced and the mechanism by which they inhibit induction of autoimmunity is crucial and has not yet been elucidated.
Recently, the expression of the transcription Foxp3 factor was shown to be enriched in CD4+CD25+ Treg cells and forced expression of Foxp3 was shown to convert murine naïve T cells into regulatory T cells. Foxp3 may initiate a genetic program that converts naïve T cells into anergic cells, which then function as Tregs.
In this work, we propose to study the central role of Foxp3 in inhibiting effector functions, inducing anergy, and generating regulatory T cells in vivo. This work will permit me to study the molecular mechanisms of tolerance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine immunology autoimmune diseases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.