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Lung stem cells and small-cell carcinoma

Objective

The existence of tumourigenic stem cells has been described in a number of solid tumours, and recent evidence suggests the existence of a similar cell population in lung adenocarcinomas.

This proposal will utilise mouse models of human small-cell lung cancer (SCLC) to address the relationship between tissue stem cells and cancer stem cells and whether non-small cell lung cancer (NSCLC) and SCLC are derived from a common tumourigenic progenitor.

Results obtained from this study should advance our understanding of the cellular and molecular mechanisms underlying lung disease and are expected to directly translate in the clinic, though the identification of early diagnosis markers, new prevention strategies and more efficient therapies.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

FP6-2005-MOBILITY-7
See other projects for this call

Funding Scheme

IIF - Marie Curie actions-Incoming International Fellowships

Coordinator

VERENIGING HET NEDERLANDS KANKER INSTITUUT
Address
Plesmanlaan 121
Amsterdam
Netherlands