Objective
This project addresses a fundamental and pressing question in gene regulation: the function of microRNAs (miRNAs). Discovered only in the last decade, these small (~22 nt) RNAs represent an important new class of molecules and are expected to play large, and previously unrecognized, roles in numerous cellular pathways.
We propose to use murine cytomegalovirus (MCMV) as a tool to study miRNA function, by examining the target specificity of the MCMV miRNAs, and the influence of the miRNAs on the gene pathways involved in infection. Specifically, this project will utilize microarray and proteomic strategies to define the gene factors whose expression is altered by viral miRNAs.
Results will be mapped onto viral and host gene networks in order to examine the local or global influence of each miRNA. Overall, the planned studies will provide critical new information on the function of mircroRNAs in a viral system and will shed light on viral/host interactions important for infection.
The results will provide an important framework with which to evaluate miRNA function in other (potentially more complex) systems. Novel detection strategies for miRNAs will also be explored, as these RNA molecules are expected to represent a new class of biomarkers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine immunology
- natural sciences biological sciences microbiology virology viromes
- natural sciences biological sciences genetics RNA
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.