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Content archived on 2024-05-29

Function and mechanism of viral miRNAs in cytomegalovirus infection

Objective

This project addresses a fundamental and pressing question in gene regulation: the function of microRNAs (miRNAs). Discovered only in the last decade, these small (~22 nt) RNAs represent an important new class of molecules and are expected to play large, and previously unrecognized, roles in numerous cellular pathways.

We propose to use murine cytomegalovirus (MCMV) as a tool to study miRNA function, by examining the target specificity of the MCMV miRNAs, and the influence of the miRNAs on the gene pathways involved in infection. Specifically, this project will utilize microarray and proteomic strategies to define the gene factors whose expression is altered by viral miRNAs.

Results will be mapped onto viral and host gene networks in order to examine the local or global influence of each miRNA. Overall, the planned studies will provide critical new information on the function of mircroRNAs in a viral system and will shed light on viral/host interactions important for infection.

The results will provide an important framework with which to evaluate miRNA function in other (potentially more complex) systems. Novel detection strategies for miRNAs will also be explored, as these RNA molecules are expected to represent a new class of biomarkers.

Fields of science (EuroSciVoc)

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Keywords

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

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FP6-2005-MOBILITY-7
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

IIF - Marie Curie actions-Incoming International Fellowships

Coordinator

UNIVERSITY OF EDINBURGH
EU contribution
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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