Objective
Dendritic cell specific intercellular adhesion molecule 3 grabbing non-integrin (DC-SIGN, CD209), a C-type lectin on the surface of immature monocyte derived dendritic cells, plays a key role in the transmission of human immunodeficiency virus (HIV) from d endritic cells to T cells. DC-SIGN captures HIV in vitro and transmits it very efficiently to target cells. This can be mimicked in a cell culture model using B-cell lines ectopically expressing DC-SIGN; we have found that only a very limited number of cell types are able to transmit virus. The mechanism of capture/transmission is largely unknown. We are especially interested in the role that internalization of the DC-SIGN/virus complex plays for transmission. This is very difficult to assess in dendritic c ells due to their complex nature. Our cell culture model provides the tools to answer this question. Comparison of cell types that are or are not capable to transmit DC-SIGN associated virus will provide insight into the role internalization plays. Using biochemical and microscopical means we want to identify subcellular localization of DC-SIGN in the different cell systems in response to challenge with virus and/or biological binding partners, such as intercellular adhesion molecules, or mannan. Knowledge about this mechanism would be needed if this early interaction of HIV with dendritic cells in the mucosal tissue should be tackled for an antiretroviral intervention strategy. Interruption of this interaction would provide a possibility for preventive measures against HIV/AIDS.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases viral diseases RNA viruses HIV
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.