Objective
Iron is an essential mineral. Both excess and lack of iron are detrimental to life-function. In mammals highest iron use is in the red blood cell (RBC), and iron from senescent RBCs is recycled for erythropoiesis through the macrophage (MP). Understanding the regulation of systemic iron recycling has made progress through the detection of hepcidin that regulates iron release from MPs and intestinal iron import.
Cellular iron metabolism is regulated in mammals mainly post-transcriptionally by the two iron regulatory proteins (IRPs). IRPs sense cellular iron status and regulate proteins of iron metabolism by binding to an RNA stem loop structure when cells are iron deplete. In mice with targeted deletions of IRP2 misregulation of proteins involved in iron metabolism, including ferritin, leads to improper iron distribution, anaemia, high serum ferritin and late onset neurodegeneration.
Our preliminary finding that ferritin in bone marrow resident MPs of IRP2-/- mice is low, while ferritin content in bone marrow de rived MPs cultured from IRP2-/- mice is high suggests that ferritin is secreted from MPs by a systemically regulated pathway that is disrupted in IRP2-/- mice. This implies a tight link between cellular and systemic regulation of iron metabolism. My lab will focus on two very different aspects of systemic iron distribution and effects of its disruption.
One project will characterize the mechanism of ferritin trafficking in wild type and IRP2-/- mice. We will explore the possibility that secreted ferritin is involved in cell to cell iron distribution and that ferritin plays an active role in the neuropathology of the IRP2-/- mice and in other neurodegenerative diseases where homeostasis of brain iron distribution is disrupted such as Parkinson's disease.
The second project will characterize the immunologic response of MPs to erythrophagocytosis and will explore the effect of the MP state after this daily event on immune homeostasis and iron recycling.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- engineering and technology environmental engineering waste management waste treatment processes recycling
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
HAIFA
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.