Objective
Recent work suggests that all eukaryotes, irrespective of their lifestyle, anaerobic or parasitic, contain an organelle derived from the mitochondrion a mitochondrial homologue, posing the question is there a common conserved function shared by all mitochondrial homologues that makes them vital for the eukaryotic cell?
I will use an innovative comparative bioinformatics approach to identify the cohort of mitochondrial proteins conserved among genomes of diverse parasitic and anaerobic eukaryotes with mitochondrial homologues of different sorts (including hydrogenosomes and mitosomes), and contrast these with the well-characterized proteomes of classic aerobic mitochondria from model organisms.
I will also investigate how these proteins might potentially interact and thus infer a mitochondrial functional interactome. These analyses will identify the best candidates for a common essential function (if one indeed exists) for the mitochondrial organelle under diverse living conditions, but will also illustrate the variability of this apparently vital eukaryotic organelle.
I will do this work at Newcastle University in the laboratory of Prof. Martin Embley, an expert on mitochondrial homologues of parasitic protozoa. My skills in bioinformatics complement those of Prof. Embley and his collaborators ensuring an excellent synergy and training environment and, through collaboration with researchers in Prof Embleys lab, a unique opportunity to use computational biology to direct focused cell biology.
My project is innovative and original and addresses major EU concerns: investigating the functions of organelles of important human parasites addresses a specific goal of EU priority Advanced Genomics and its applications for Health (OJL294, 29.10.02). My project will also provide baseline data for inferring potential minimal functions and structure of mitochondria generally; a Life Sciences Priority (LSH-2003-1.2.2-3).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology protozoology
- natural sciences biological sciences cell biology
- natural sciences biological sciences genetics genomes
- natural sciences computer and information sciences databases relational databases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NEWCASTLE UPON TYNE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.