Objective
This proposal contains fundamental science, but within one of the central aspects that make plants of vital importance for humanity: their growth and development. It is increasingly clear that biomass is one of the few sustainable energy alternatives. The mitogen-activated protein kinase (MAPK) phosphorylation cascades are conserved signalling modules in all eukaryotes and have pivotal roles to regulate cell division and cell growth in animals but such roles in plants are just emerging. Specifically, in my work I recently discovered that group D MAPK kinases potentially regulate plant growth and development. Within this project I propose to focus on MKK9, because it is also stress induced, and bioinformatics analysis shows co-regulation with genes important in growth and environmental adaptation. A close collaboration between the School of Biological Sciences, and the Computer Sciences at Royal Holloway, University of London, will enable me to build a novel system's biology approach to reach my goals.
My work program is designed around six modules;
1. molecular genetics studies of MKK9 by analysing insertional mutants, RNAi and over-expression lines,
2. detailed phenotypic analysis of these lines
3. genome-wide transcriptomics with inducible gain of function mutant forms to find downstream targets,
4. bioinformatics analysis of the transcriptome data that we obtain, and the public databases to find candidate target genes, and coregulated genes,
5. high-throughput functional analysis of the MKK9 signalling pathway by a cell transfection system and promoter reporter gene readout and finally
6. model building that utilise gene antology (GO) terms and computer language, which will allow to make predictions and plan further experiments on the whole plant level towards the goal of attaining plants with better yield and stress tolerance.
This multidisciplinary program should enable me to reach professional maturity and to establish a research career upon return to Hungary.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences molecular biology molecular genetics
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EGHAM
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.