Objetivo Regeneration is a complex biological process by which animals restore the shape, structure, and function of body parts lost to injury or experimentally amputated. Only a few vertebrate species retain a significant regenerative capacity during adulthood. With respect to the heart, the extraordinary ability of newts to regenerate significant sections of the heart has been known for over 30 years.However, the molecular and cellular mechanisms underlying this phenomenon remain largely unexplored, most probably owing to the intrinsic experimental difficulties and relative lack of genetic tools in this model system. Recently, it has been shown that adult zebrafish also display a remarkable ability to regenerate extensive portions of the heart after amputation.In this project, we propose to take advantage of the powerful tools of genetic manipulation, genomic analysis, in vivo imaging, and reverse-genetics mutagenesis screenings available in the zebrafish, to undertake the following specific aims:1) to identify and characterize the molecular mechanisms associated with the regenerative response of the zebrafish heart;2) to characterize the changes in cell behavior dynamics associated with zebrafish heart regeneration;3) to identify novel genes required for regeneration in the zebrafish.We feel confident that detailed analyses of zebrafish heart regeneration, such as the one proposed herein, in addition to bolstering our understanding of this fascinating biological phenomenon, will provide valuable clues for the implementation of strategies of regenerative medicine. Ámbito científico ciencias médicas y de la saludbiotecnología médicaingeniería genéticaciencias médicas y de la saludbiotecnología médicatecnologías celularescélulas madre Palabras clave Nuclear reprogramming cell differentiation stem cells Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Convocatoria de propuestas FP6-2004-MOBILITY-12 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador CENTRE DE MEDICINA REGENERATIVA DE BARCELONA Dirección Dr. aiguader, 88 Barcelona España Ver en el mapa Enlaces Sitio web Opens in new window Aportación de la UE Sin datos
