Obiettivo Regeneration is a complex biological process by which animals restore the shape, structure, and function of body parts lost to injury or experimentally amputated. Only a few vertebrate species retain a significant regenerative capacity during adulthood. With respect to the heart, the extraordinary ability of newts to regenerate significant sections of the heart has been known for over 30 years.However, the molecular and cellular mechanisms underlying this phenomenon remain largely unexplored, most probably owing to the intrinsic experimental difficulties and relative lack of genetic tools in this model system. Recently, it has been shown that adult zebrafish also display a remarkable ability to regenerate extensive portions of the heart after amputation.In this project, we propose to take advantage of the powerful tools of genetic manipulation, genomic analysis, in vivo imaging, and reverse-genetics mutagenesis screenings available in the zebrafish, to undertake the following specific aims:1) to identify and characterize the molecular mechanisms associated with the regenerative response of the zebrafish heart;2) to characterize the changes in cell behavior dynamics associated with zebrafish heart regeneration;3) to identify novel genes required for regeneration in the zebrafish.We feel confident that detailed analyses of zebrafish heart regeneration, such as the one proposed herein, in addition to bolstering our understanding of this fascinating biological phenomenon, will provide valuable clues for the implementation of strategies of regenerative medicine. Campo scientifico scienze mediche e della salutebiotecnologia medicaingegneria geneticascienze mediche e della salutebiotecnologia medicatecnologie cellularicellule staminali Parole chiave Nuclear reprogramming cell differentiation stem cells Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Invito a presentare proposte FP6-2004-MOBILITY-12 Vedi altri progetti per questo bando Meccanismo di finanziamento EIF - Marie Curie actions-Intra-European Fellowships Coordinatore CENTRE DE MEDICINA REGENERATIVA DE BARCELONA Indirizzo Dr. aiguader, 88 Barcelona Spagna Mostra sulla mappa Collegamenti Sito web Opens in new window Contributo UE Nessun dato
