Objective
Mitochondrial dysfunction and oxidative stress are associated with neurodegenerative diseases, ischemia reperfusion injury of heart and brain, cancer and aging. Most research efforts regarding oxidative stress so far have focused on reactive oxygen species (ROS) mediated cell damage (oxidized lipids, protein and nucleic acids) and cell death (apoptosis and/or necrosis).
However, the role of hydrogen peroxide as a signalling molecule under physiological and pathophysiological conditions has been largely unexplored. In my recent study, we have identified a novel ROS homeostatic cycle dependent on the induction of PGC-1s. PGC-1alpha is a transcriptional coactivator that translates different physiological stimuli (cold, exercise, fasting) into specific metabolic programs (adaptive thermogenesis, muscle fiber-type switching, liver gluconeogenesis).
Indeed, PGC-1alpha has emerged as a master regulator of mitochondrial biogenesis and respiration. Hence, my future work will be based on this novel homeostatic cycle as a potential system to study ROS-mediated signalling pathways.
Future aims:
- to analyze and map the protein-signalling cascade: from hydrogen peroxide stimulation to induction of PGC-1alpha and ROS defence systems;
- to study the role of ROS as a more general transducer of environmental cues to PGC-1alpha induction and mitochondrial biogenesis;
- to study the role of PGC-1alpha, oxidative stress signalling, and mitochondrial biogenesis in malignant transformation models.
This research promises to increase the understanding of hydrogen peroxide as a signalling molecule, rather than its role as a general toxin. Furthermore, implementation of this novel ROS homeostatic system in models of diseases related to oxidative stress could aid tremendously in identifying new potential targets for therapeutic intervention.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences chemical sciences organic chemistry organic acids
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
HAIFA
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.