Objective
Telemetries are essential in maintaining the stability of chromosome ends and are synthesized by a specialized enzyme named telemetries. Telemetries are not expressed in most somatic cells but are over expressed in a large number of tumours and are involved with cell immortalisation and tumorigenesis processes. This differential expression was the initial rationale for the evaluation of telemetries inhibitors as potential anticancer drugs. The peculiar structure of telemetries, composed of Guanine repeats, allows forming an unusual DNA conformation based on a Guanine-quadruple (G-quadruple). In vitro, G-quadruple DNA inhibits telemetries activity, which has recently stimulated the search for legends that stabilize telemetric DNA under its G- quadruple conformation, as a new strategy to impair telemetries function in cancer cells. We have developed monomer MMQ and dimerism macro cyclic BOQ quinacridine (dibenzophenanthroline) derivatives that are strong G-quadruple interactive legends and potent telemetries inhibitors. The first objective of the research project is the improvement of the binding selectivity of the MMQ series. This will be achieved by the synthesis of polyamide- trisubstituted MMQ conjugates. This new generation of legend is hoped to achieve specific recognition of quadruple DNA in combining two binding modes, namely G-quartet stacking and anchorage in three grooves. The second objective of the research project is the evaluation of the potential of the BOQ macro cycles as selective G4 binders. This will be conducted through biophysical and biochemical studies of interactions of the BOQ series with various oligonucleotides forming quadruple. In addition, fluorescent derivatives of BOQ will be prepared in order to use them as quadruple-DNA probes both in vitro and in vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.