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Molecular mechanisms of amino acid recognition by adenylation domains of the Streptomyces coelicolor A3 (2) coelichelin nonribosomal peptide synthetase

Objectif

Non-ribosomal peptide synthetases (NRPSs) are a large family of modular multienzymes that catalyse the biosynthesis of many commercially important microbial natural products. Adenylation (A) domains within each NRPS module selectively bind and activate (by reaction with ATP) the amino acids constituting the peptide. Structure based models of A-domains have recently been developed, which identify potentially important residues for amino acid recognition and facilitate the prediction of new peptide natural pr oduct structures from genome sequence data. The accuracy of these structural predictions and the role played by putative recognition residues will be investigated using the Streptomyces coelicolor A3(2) coelichelin synthetase as a model.

Champ scientifique (EuroSciVoc)

Mots‑clés

Thème(s)

Appel à propositions

FP6-2002-MOBILITY-5
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Régime de financement

EIF - Marie Curie actions-Intra-European Fellowships

Coordinateur

UNIVERSITY OF WARWICK
Contribution de l’UE
Aucune donnée
Adresse
Gibbet Hill Road
COVENTRY
Royaume-Uni
Coût total
Aucune donnée