Objective
Europe is the oldest continent and is rapidly aging. The aim of the IP GEHA is to identify genes involved in healthy aging and longevity, allowing individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age-related diseases. To achieve this aim a coherent, tightly integrated program of research that unites demographers, geriatricians geneticists, genetic epidemiologists, molecular biologists, bioinfomaticians and statisticians has been set up. The genetic analysis will be performed by 8 high throughput platforms, within the framework of a centralized database. The working plan of this IP is to: i) collect an unprecedented number (2550) of long-lived (90+) sibpairs from 10 European countries; ii) perform a genome scan by microsatellites in all the sibpairs (a total of 5100 individuals) iii) refine the regions identified by the genome scan by a linkage disequilibrium (LD) mapping using SNPs in cases (i.e. the 2550 probands of the sibpairs) and in 2550 younger controls who will also be recruited, followed by positional cloning and mutational analysis. Three regions in chromosome 4 (D2S1564), 11(11.p15.5) and 19 (around APOE gene) suggested to be involved in aging and longevity in previous studies, will be investigated for their LD block structure in CEPH families and then by an economic number of SNPs in the entire collection of recruited people.
All the recruited people will also be genotyped mitochondrial DNA haplogroups and mutations known to play a major role in aging and longevity. Additional advanced approaches (bioinformatics, advanced statistics, mathematical modelling, functional genomics and proteomics, molecular genetics) are envisaged to identify the gene variant(s) of interest. The experimental design will also allow i) to identify gender-specific genes involved in healthy aging and longevity in women and men; ii) to develop mathematical and statistical model.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences molecular biology molecular genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences mathematics applied mathematics statistics and probability
- natural sciences biological sciences genetics genomes
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BOLOGNA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.