Objective
Coronary artery disease (CAD) and atherothrombosis (AT) kills more individuals in Europe than any other disease. 600,000 people are diagnosed with myocardial infarction (Ml) yearly, with 50% being fatal and many survivors experiencing a reduction in quality of life. Long-term aspirin provides a cheap approach to the prevention of Ml. However, its use is associated with unacceptable side effects, thus emphasising the need for the identification of markers to detect individuals at risk of CAD and AT. Such markers are not currently available. However, completion of the human genome sequence and high-throughput sequencing and typing of single nucleotide polymorphisms, together with new technologies such as microarray analysis, proteomics and RNA interference, provide a unique opportunity for their identification. Development of better drugs for the prevention and treatment will also be facilitated by a greater understanding of the mechanisms of platelet interaction with the damaged vessel wall and with other blood cells. We bring together leading European scientific and medical expertise to reap the benefits of the completion of the human genome, by identifying genetic risk factors for CAD & AT through research that spans the clinical-basic science interface. Our studies will result in health gains and wealth creation. The project will generate population genetics data providing insight into the causes of CAD & AT through the identification of tributory genes and gene variants, proteins and intracellular signalling pathways. Our globally competitive programmes of cell biology and protein research will determine the physiological roles of identified proteins. The likelihood of achieving our ambitious goals is greatly increased by bringing together five leading clinical CAD centres, academic groups specialised in cell biology/signalling/haematopoieses and proteomics as well as Europe's premier genome centre, The Wellcome Trust Sanger Institute.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.