Objective
In response to urgent medical and societal needs for novel immunotherapies for cancer and chronic infections and for prophylactic vaccination, optimised delivery systems for vaccine targeting to dendritic cells will be developed and clinically evaluated. The approach will rely on two new antigen delivery vectors, the detoxified adenylate cyclase toxoid (ACT) and the porcine parvovirus-like particles (PPV-VLP) which were recently shown to target dendritic cells very efficiently and specifically, allowing highly efficient presentation of delivered antigens to T cells. These vaccine vectors enable the induction of strong, specific and protective immune responses and have an established record of safety and efficacy in preclinical animal models. Under this project, academia experts in immunology, vaccinology, molecular biology and structural biology have joined forces with toxicologists, clinicians and vaccine production experts of two companies, in order to translate these novel vaccine technologies from research into clinical application. Based on the preclinical record of ACT-based vaccines in animal models, the leap into safety and efficacy Phase l/ll human clinical trial will be made with an ACT-based construct delivering the tyrosinase A.2 epitope as a therapeutic vaccine for metastasic melanoma.
Simultaneously to GMP batch production, development and clinical testing, in-depth analysis of the cellular and molecular mechanisms and of the structural basis of ACT interaction with dendritic cells will be conducted, by placing particular emphasis on gaining new knowledge for further improvement of the delivery capacity of the ACT molecule towards enhanced efficiency and broader versatility in clinical use. The PPV-VLP vector will be developed in parallel by defining its cellular receptor and trafficking inside dendritic cells,preclinical efficacy and toxicology, in order to bring this alternative vaccine carrier to the level of clinic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer melanoma
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine immunology immunotherapy
- medical and health sciences basic medicine toxicology
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.