Objective
Migraine is a common chronic pain syndrome, with recurrent attacks (1-3 days) of disabling headache,associated symptoms and, in 1/3 of patients, neurological aura symptoms. Over 12% of the general population (2/3 females) have migraine attacks regularly (median 18/year). WHO rates migraine in the highest class of most disabling chronic disorders. Migraine-related annual costs in the EU amount 10 billion euros. Acute attack treatments are satisfactorily in less than half of patients. Effective and well-tolerated prophylactic migraine agents are dearly needed.Genetic factors are involvedin the mechanisms for the attack, pain, and aura. EUROHEAD aims to identify and validate these genes, and unravel their functional involvement in migraine pathways by using clinical and (post)genomic techniques in patients and cellular and transgenic mouse models. To this extent, EUROHEAD combines the extensive clinical, genetic and neurobiologic expertise of leading scientists from 7 EU countries and access to a unique patient material. This includes large well-defined families, clinic-and population-based cohorts, families from genetic isolated populations (Finland; Costa Rica and 600,000 twin pairs from the EUfunded GENOMEUTWIN project.We assume that rare familial and common complex types of migraine share common genes and pathways.Focusing on families and isolates, integrated genome wide scans linkage disequilibrium mapping, bioinformatics and association studies will yield candidate genes. The function will be studied by using electrophysiological (e.g. cortical spreading depression), behavioural, and neuroimaging models Endophenotypes will be identified in clinical, attack-provocation, neurophyiological, and neuroimaging studies.The project will improve our understanding of the genetics and neurobiology of migraine, including molecular diagnostics and intervention targets. There are ample opportunities for SME' s and pharmaceutical companies to participate...
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences inorganic chemistry alkali metals
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9600 LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.