Objective
Bone is among the most frequently transplanted tissues and autography account for the majority of bone graft procedures. However, auto grafts always require a secondary surgery adding high costs to health services increase patient morbidity and are available in very limited quantities. Therefore, there is widespread interest around the world for programmes to rebuild and restore function of degenerative tissue using artificial implant materials. The enormous need for bone grafts and the recent progresses in biomedical and biomaterial sciences have stimulated the rapid growth and expansion of a new field: bone tissue engineering. However, this approach presents important limits to the transfer from an academic to a routine clinical environment: high cost, difficulties in transferring biological samples between hospitals and centralized "cell factories"; reproducibility due to lack of standards. The aim of this project is to combine the developments in the areas of tissue engineering based on materials and 3D scaffolds development with largely laboratory and few commercial activities in the field of bioreactors and transpose the concepts of tissue engineering and regeneration of the frontiers of new developments: the automated production of antilogous bone replacement materials The goal of this project is to develop a bioreactor that would be set-up within the confines oaf hospital and which would be used to homogenously activate specially designed porous matrices with stem cells from harvested bone marrow aspirates of the patient to produce antilogous hybrid bone graftmaterials.This target will be achieved through the following scientific and technical objectives:
1) design and production of innovative bioreactors,
2) design and production of novel biomaterials and scaffolds architectures tailored for both bioreactor use and bone tissue engineering,
3) validation of the approach in preclinical animal studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology bioremediation bioreactors
- medical and health sciences clinical medicine surgery
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences medical biotechnology implants artificial bone
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-NMP-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.