Objective
In recent years, with consumer trends towards fresher and safer foods, there has been increasing interest in alternative methods for food preservation. These include innovative techniques such as high electric field pulses or ultrahigh pressures, and also combined processes of several agents such as mild heat, natural antimicrobials or low pH. The main problem encountered for the implementation of these new approaches is the lack of knowledge on the effect of the different agents on microorganisms. A better understanding of bacterial inactivation and resistance mechanisms would help in defining safer processes. The resistance of foodborne pathogens such as Salmonella and Escherichia coli to environmental stresses is an increasingly important area of microbio logy. These microorganisms have developed adaptive networks which can be triggered in response to many inimical processes used in the food industry, inducing the expression of genes involved in cellular defence mechanisms. The modification of sigma factors (?) bound to core RNA polymerase, conferring promoter specificity, is possibly the most important regulatory mechanism in gramnegative cells. However, apart from the common regulatory networks, also specific stress resistance mechanisms are present in bac terial cells. In this project we will study the role of general and specific resistance mechanisms in Salmonella against several agents used in food preservation, through the isolation of naturally occurring mutants of either increased or reduced resistanc e. Mutant strains on the general regulation networks (genes encoding for the RNA polymerases sigma factors ?5 and ?32) and strains specifically more resistant to one single agent (either heat, acid, high electric field pulses or oxidative stress) will be s elected and characterized with the final objective of identifying those proteins involved on a higher or lower resistance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ZARAGOZA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.