Objective
A hallmark of cellular ageing is the increase in the oxidatively modified proteins. Oxidative damage in lymphocytes is critical given the importance of the immune system for maintaining good health and for successful ageing. Some antioxidant micronutrients in the diet, such as zinc, trol the development and function of the immune cells, the activity of stress-related proteins [metallothioneins, chaperones, ApoJ, PARP-1, NO, MsrA] and antioxidant enzyme (SOD) and help to maintain genomic integrity and stability, thus suggesting diet-gene interactions. During ageing, the intake of zinc decreases due to inadequate diet or/and intestinal malabsorption, thus causing frailty, general disability and increased incidence of age-related degenerative diseases (cancer, infections and atherosclerosis). No focused research has been performed thus far to clarify the intrinsic biochemical mechanisms and the impact of nutrient zinc on the genome during immunosenescence. The applicants will therefore study, the role of zinc in the gene expression and functions of metallothioneins, chaperones, NO, MsrA, ApoJ, telomerase, PARP-1 and DNA-repair as a function of immunosenescence in lymphocytes from old subjects including nonagenarians, as well as in ill old patients affected by age-related diseases and in T-cell clones as in vitro model. Particular attention will be paid to the processing of oxidised proteins by proteasome, which decreases in ageing. The activity of all proteins herein studied is impaired in ageing and this is directly and indirectly trolled by zinc ion bioavailability. The zinc deficiency in the elderly will be evaluated through the screening of polymorphic allele frequency of proteins involved in zinc ion metabolism (such as Hsp70-2 and TNF-alpha) and their relationships to gender. The results will form a rationale for the promotion of healthy ageing through a zinc supplementation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences nutrition
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-FOOD-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ANCONA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.