Objective
Systemic hypertension is one of the most prevalent diseases among the population of our country, and it also has a very big social and economic repercussion. Renal injury is one of its most important complications, and it is also one of the main sources of chronic renal insufficiency. Uncontrolled hypertension damages renal function by two basic mechanisms: intraglomerular hypertension and renal hypertrophy, leading to glomerular sclerosis by a common mechanism involving the action of autocrine or paracrine mediators like angiotensin II (All) and transforming growth factor ÿ1 (TGF-ÿ1 ). TGF-ÿ1 is very important in the mediation of this process, due to its role in the regulation of cellular proliferation, and also in the synthesis and degradation of extracell ular matrix (ECM). This cytokine seems to have an important role in the induction and development of interstitial fibrosis; its sustained expression induces chronic and progressive tissular fibrosis. TGF-ÿ systemic administration causes an elevation of the tissue levels of All, that also induces interstitial fibrosis in mesangial cells and in nephron tubular epithelium, causing ECM accumulation; moreover, All induces TGF-ÿ1 synthesis in mesangial cells, proximal tubule epithelial cells and vascular smooth m uscle cells. TGF-ÿ1 induces the expression of the prooncogenic GTPase Ras, and both molecules cooperate synergically in the progression of undifferentiated invasive tumours. TGF-ÿ1 enhances significantly the Ras mitogenic effects. However, Ras can also inh ibit cellular hypertrophy and ECM synthesis induced by TGF-ÿ1 signalling. Both TGF-ÿ1 and All induce the expression of connective tissue growth factor (CTGF), hypertrophie cytokine that maintains cells in d phase of the cell cycle. CTGF may be a mediator o f the profibrotic effects induced by TGF-ÿ. The aim of this project is the analysis of TGF-ÿ1 mediation in All-induced ECM synthesis, the possible implication of Ras #
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SALAMANCA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.