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Content archived on 2024-05-29

Involvement of RAS signalling in TGF-ss1-mediated extracellular matrix synthesis relathionship between TGF-ss1 and angiotensin II

Objective

Systemic hypertension is one of the most prevalent diseases among the population of our country, and it also has a very big social and economic repercussion. Renal injury is one of its most important complications, and it is also one of the main sources of chronic renal insufficiency. Uncontrolled hypertension damages renal function by two basic mechanisms: intraglomerular hypertension and renal hypertrophy, leading to glomerular sclerosis by a common mechanism involving the action of autocrine or paracrine mediators like angiotensin II (All) and transforming growth factor ÿ1 (TGF-ÿ1 ). TGF-ÿ1 is very important in the mediation of this process, due to its role in the regulation of cellular proliferation, and also in the synthesis and degradation of extracell ular matrix (ECM). This cytokine seems to have an important role in the induction and development of interstitial fibrosis; its sustained expression induces chronic and progressive tissular fibrosis. TGF-ÿ systemic administration causes an elevation of the tissue levels of All, that also induces interstitial fibrosis in mesangial cells and in nephron tubular epithelium, causing ECM accumulation; moreover, All induces TGF-ÿ1 synthesis in mesangial cells, proximal tubule epithelial cells and vascular smooth m uscle cells. TGF-ÿ1 induces the expression of the prooncogenic GTPase Ras, and both molecules cooperate synergically in the progression of undifferentiated invasive tumours. TGF-ÿ1 enhances significantly the Ras mitogenic effects. However, Ras can also inh ibit cellular hypertrophy and ECM synthesis induced by TGF-ÿ1 signalling. Both TGF-ÿ1 and All induce the expression of connective tissue growth factor (CTGF), hypertrophie cytokine that maintains cells in d phase of the cell cycle. CTGF may be a mediator o f the profibrotic effects induced by TGF-ÿ. The aim of this project is the analysis of TGF-ÿ1 mediation in All-induced ECM synthesis, the possible implication of Ras #

Fields of science (EuroSciVoc)

Keywords

Topic(s)

Call for proposal

FP6-2002-MOBILITY-11
See other projects for this call

Funding Scheme

ERG - Marie Curie actions-European Re-integration Grants

Coordinator

UNIVERSIDAD DE SALAMANCA
EU contribution
No data
Address
Patio de Escuelas, 1
SALAMANCA
Spain
Total cost
No data