Objective
Allogeneic stem cell transplantation (SCT) still remains the only cure for a variety of malignant, non-malignant haematological diseases and disorders of the immune system. The success of SCT is limitedby post transplant related complications; including li fe threatening infections, relapse of malignantdisease and most notably graft versus host disease (GVHD). It is estimated that between 25-60% sufferfrom GVHD in either its acute or chronic form. Research has implicated the antigen presenting cells(APCs) of the immune system as the initiators of GVHD. Current data suggests that the origin (fromeither patient of donor) of these cells is important. The identification of novel antibodies to APCs anddendritic cells (DC) in particular provide new tools to further the investigation of DC in theimmunobiology of GVHD, and as a consequence a possible role for these novel antibodies for targetedGVHD immunotherapy. Current immunosuppressive prophylaxis is split between traditional drugssuch as cyclosporine and methotrex ate and immunotherapeutics such as antibodies directed againstcertain cell populations. Campath - a CD52 monoclonal antibody has been shown to not only deplete Tcell but also blood DC. T cell depletion is the treatment option for patients with high risk of GVHD,however the disadvantage of such as agent is increased susceptibility to infections and disease relapse.This research aims to use these novel antibodies to further unlock the exact role of host (patient) anddonor DC in GVHD immunobiology. At the same time these antibodies will be compared with acurrent antibody (Campath) in the modulation of GVHD through the use of a human in vitro model ofGVHD and two in vivo chimeric human/murine models of GVHD. This will also provide importantdata for the compariso n of such models in GVHD research with relevance to the clinical pathology.To fulfill this research this fellowship will enable the mobility of a #
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine emergency medicine graft versus host disease
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
NEWCASTLE UPON TYNE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.