Final Report Summary - GENOSEPT (Genetics of sepsis in Europe)
The project sought to provide important data on gender-related mortality and morbidity. It would have a major impact on diagnosis and treatment of European sepsis patients in subsequent therapeutic trials by targeting risk sub-populations and focusing expensive new treatments. Furthermore, it would also standardise protocols for genotyping, facilitate application of new knowledge in functional and structural genomics, harmonise high-throughput genotyping and quality control between major European centres, as well as contribute to reducing sepsis-related mortality in European healthcare.
Amongst the results achieved were the following:
- the development of electronic Case report forms (eCRFs);
- the engagement of national coordinators in their role in helping their local Intensive care units (ICUs) recruit patients for the study;
- obtained ethics approval for ICUs in Europe and Israel;
- the recruitment of more than 2500 patient Europe-wide (and Israel) for genome wide genotyping;
- the verification of the quality and content of the eCRFs for each patient;
- the process of blood samples for genotyping;
- the evaluation of candidate genes and markers suitable for genotyping relative to sepsis;
- the evaluation of genotyping tests;
- the evaluation of study designs for the genotyping;
- the pursue of a scientific and statistical analysis of the first step of genotyping and association of the genetic variants with the primary study endpoint, namely the mortality;
- the pursue of a statistical analysis of genotype versus phenotype of patients;
- the promotion of genomic research in eastern European countries.