Objective
The project deals with the development, analysis and application of coarse-grained models for the study of macromolecules of biological importance. The size and operational time scale of these molecules often prevent a direct application of more detailed calculations and descriptions, and requires the development of computationally efficient, yet physically sound, coarse grained models. Since biological macromolecules operate in an aqueous environment characterized by a huge thermal noise, these models are stochastic in nature and constitute a challenge for the field of non-equilibrium statistical physics.
The project is divided into three research objectives. In the research objective 1, I propose a rigorous study of the kinetics of motor proteins with the help of methods of statistical physics. The generalization of these theories is important for a number of problems of biological relevance, as polymer translocation and DNA/RNA packing in viruses. The characterization of equilibrium properties of polymers of arbitrary stiffness in confined geometries constitutes the main focus of the research objective 2. Analytical methods and Monte Carlo computer simulations are used to calculate probability distribution functions and entropic forces with a number of different boundary conditions. Applications are foreseen in biophysical studies of F-actin, DNA, microtubules and other protein filaments.
The research objective 3 aims at the conceivement and application of computationally efficient coarse-grained models for the investigation of protein structures of considerable size. A considerable part of the project is dedicated to the introduction of the electrostatic interaction in Go models, an essential step to address the study of the function of proteins, given their structure. The validity of the proposed models will be assessed through a comparison with more detailed calculations for a number of target biomolecules of small size.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences polymer sciences
- natural sciences physical sciences classical mechanics statistical mechanics
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARI
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.