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Design of new nucleosides for DNA interactions and fluorescent studies

Objectif

The strategy of replacing DMA natural bases by non-polar surrogates has opened ways to add new functions to the DNA structure, to probe protein-DNA interactions, to test DMA repair enzymes, to stabilize structure, and to probe the internal features of the helix. Also, different fluorescent species named fluorosides, which have been shown an increasingly useful tool for bio-molecular analysis and is applied widely in the biosciences.

This project wants to develop a new series of nucleosides with different characteristics. One group will have different steric demanding nucleosides which will be used to study the interaction with DNA polymerase enzyme and the other group will have fluorescent activity which will be evaluated as a molecular tags.

Champ scientifique (EuroSciVoc)

Thème(s)

Appel à propositions

FP6-2002-MOBILITY-6
Voir d’autres projets de cet appel

Régime de financement

OIF - Marie Curie actions-Outgoing International Fellowships

Coordinateur

UNIVERSIDAD AUTÓNOMA DE MADRID
Contribution de l’UE
Aucune donnée
Coût total
Aucune donnée

Participants (1)