Objective
The general objective of INNOCHEM is to develop innovative chemokine-based therapeutic strategies for autoimmunity and chronic inflammation. The project is based on the scientific excellence of the applicants, which have made major recognized contributions to the field since the very beginning of chemokine discovery, and on the construction of shared technological platforms.
This will include:
- proteomics and
- transcriptional profiling for the outline of the "chemokinome" in pathophysiological conditions and identification of new antagonists;
- molecular modelling of agonist/antagonist receptor or agonist/inhibitor interaction, for pharmacology and drug design; iv) gene modified mice for target validation in autoimmune disorders.
Genetic, structural, biological, and immunopathological studies will provide a framework for the development of innovative chemokine-based therapeutic strategies. The therapeutic approaches to be investigated are innovative and not limited to conventional antagonists. These will include decoy receptors, agonist binders, and non-competitive allosteric inhibitors. In addition to academic groups, therapy-oriented research will include 3 biotech SMEs, and 3 Pharma companies. The companies involved develop complementary non-overlapping approaches to target the chemokine system with recombinant and low molecular weight molecules.
INNOCHEM is expected to conduct a "proof of principle" clinical study in volunteers in the first 18 months. The ambition of this project is to re-establish European leadership in basic and applied chemokine research by integrating academic and industrial cutting edge groups to develop innovative therapeutic strategies against autoimmunity and chronic inflammatory disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROZZANO-MILANO
Italy
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Participants (28)
BELLINZONA
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PARIS
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PARIS
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LODZ
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740238 BERLIN
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BERN
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MUNICH
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BRUSSELS
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LONDON
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FIRENZE
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COPENHAGEN
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LEUVEN
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LONDON
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MILANO
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L'AQUILA
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ALLSCHWIL
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VIENNA
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GENEVA
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SIENA
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L'AQUILA
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BELO HORIZONTE MG
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CARDIFF
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GLASGOW
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LONDON
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ROMA
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PLAN LES OUATES
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2213 REHOVOT
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MADRID
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