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Innovative chemokine-based therapeutic strategies for autoimmunity and chronic inflammation

Objective

The general objective of INNOCHEM is to develop innovative chemokine-based therapeutic strategies for autoimmunity and chronic inflammation. The project is based on the scientific excellence of the applicants, which have made major recognized contributions to the field since the very beginning of chemokine discovery, and on the construction of shared technological platforms.

This will include:
- proteomics and
- transcriptional profiling for the outline of the "chemokinome" in pathophysiological conditions and identification of new antagonists;
- molecular modelling of agonist/antagonist receptor or agonist/inhibitor interaction, for pharmacology and drug design; iv) gene modified mice for target validation in autoimmune disorders.

Genetic, structural, biological, and immunopathological studies will provide a framework for the development of innovative chemokine-based therapeutic strategies. The therapeutic approaches to be investigated are innovative and not limited to conventional antagonists. These will include decoy receptors, agonist binders, and non-competitive allosteric inhibitors. In addition to academic groups, therapy-oriented research will include 3 biotech SMEs, and 3 Pharma companies. The companies involved develop complementary non-overlapping approaches to target the chemokine system with recombinant and low molecular weight molecules.

INNOCHEM is expected to conduct a "proof of principle" clinical study in volunteers in the first 18 months. The ambition of this project is to re-establish European leadership in basic and applied chemokine research by integrating academic and industrial cutting edge groups to develop innovative therapeutic strategies against autoimmunity and chronic inflammatory disorders.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Coordinator

HUMANITAS MIRASOLE SPA
Address
Via Manzoni 56
Rozzano-milano
Italy

Participants (28)

ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland
Address
Via Vincenzo Vela 6
Bellinzona
UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI
France
Address
4 Place Jussieu
Paris
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac 101
Paris
UNIWERSYTET MEDYCZNY W LODZI
Poland
Address
Al. Kosciuszki 4
Lodz
MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN
Germany
Address
Robert-roessle-strasse 10
740238 Berlin
UNIVERSITAET BERN
Switzerland
Address
Hochschulstrasse 4
Bern
LUDWIG-MAXIMILIANS-UNIVERSITY MUNICH
Germany
Address
Geschwister-scholl-platz 1
Munich
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Av. Franklin Roosevelt 50
Brussels
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
Address
Piazza S. Marco 4
Firenze
UNIVERSITY OF COPENHAGEN
Denmark
Address
Norregade 10
Copenhagen
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Exhibition Road
London
BIOXELL S.P.A.
Italy
Address
Via Olgettina, 58
Milano
DOMPE SPA
Italy
Address
Via Campo Di Pile
L'aquila
POLYPHOR LTD
Switzerland
Address
Hegenheimermattweg 125
Allschwil
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH
Austria
Address
Brunnerstr 59
Vienna
MERCK SERONO SA
Switzerland
Address
9, Chemin Des Mines
Geneva
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE S.R.L.
Italy
Address
Via Nino Bixio 15
Siena
DOMPE S.P.A.
Italy
Address
Via Campo Di Pile
L'aquila
UNIVERSIDADE FEDERAL DE MINAS GERAIS
Brazil
Address
Av. Antonio Carlos, 6627-Pampulha
Belo Horizonte Mg
CARDIFF UNIVERSITY
United Kingdom
Address
30-36 Newport Road
Cardiff
THE UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
Glasgow
QUEEN MARY & WESTFIELD COLLEGE, UNIVERSITY OF LONDON
United Kingdom
Address
Mile Road
London
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO-A.C.R.A.F. S.P.A
Italy
Address
Viale Amelia, 70
Roma
NOVIMMUNE S.A.
Switzerland
Address
14 Chemin Des Aulx
Plan Les Ouates
BIOKINE THERAPEUTICS LTD
Israel
Address
Weizmann Science Park
2213 Rehovot
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
Spain
Address
Serrano 117
Madrid