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ENFIN - an experimental network for functional integration

Objectif

We propose to form a Network of Excellence in the area of bioinformatics to provide a Europe-wide integration of computational approaches in systems biology. This network will be focused on the development and critical assessment of computational approaches in this area, but uniquely will bring together a range of backgrounds and laboratory contexts that will span investigative computer science through to traditional wet-bench molecular biology. Despite the progress in bioinformatics methods and databases, even the best experimental labs use. only a small number of computational tools in their work and rarely exploit the potential of multiple datasets. This network will enable a transformation of the way computational analysis is used in the laboratory and the infrastructure will be entirely open, analogous to the genome information. To achieve its goals, the network will internally have close collaboration between experimental and computational research, with a specific consumables budget for experimentally testing predictions. The computational work includes the development of a distributed database infrastructure appropriate for small laboratories and development of analysis methods including Bayesian networks, metabolite flux modeling and correlations of protein modifications to pathways. The experimental techniques used to test this system include mass spectroscopy, synthetic peptide biochemistry and RNAi knockdown. Where appropriate we have chosen experimental areas connected to intracellular signaling associated with the cell cycle. An additional benefit will be greater understanding in this area. Overall the ENFIN network will deliver four main products: a platform for database provision of diverse biological data (the ENFIN core), a suite of analysis tools integrated with this platform (the ENFIN analysis layer), extensive documentation written from the wet laboratory perspective and "best practice" guidelines...

Appel à propositions

FP6-2004-LIFESCIHEALTH-5
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Régime de financement

NoE - Network of Excellence

Coordinateur

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Adresse
Meyerhostrasse 1
Heidelberg
Allemagne

Participants (22)

UNIVERSITY OF DUNDEE
United Kingdom
Adresse
Nethergate
Dundee
TECHNICAL UNIVERSITY OF DENMARK
Danemark
Adresse
Anker Engelundsvej 1
Kgs. Lyngby
UNIVERSITY OF ROME TOR VERGATA
Italie
Adresse
Via Carnevale
Rome
MEDICAL RESEARCH COUNCIL
United Kingdom
Adresse
20 Park Crescent
n/a London
LUDWIG INSTITUTE FOR CANCER RESEARCH
Suède
Adresse

595 Uppsala
HELSINGIN YLIOPISTO
Finlande
Adresse
Yliopistonkatu 4
Helsingin Yliopisto, Helsinki
UNIVERSITY COLLEGE LONDON
United Kingdom
Adresse
Gower Street
London
CENTER FOR RESEARCH AND TECHNOLOGY, HELLAS
Greece
Adresse
6Th Km Charilaou-thermi Road
361 Thermi - Thessaloniki
UNIVERSITAET ZU KOELN
Allemagne
Adresse
Albertus-magnus-platz 3
Koeln
WEIZMANN INSTITUTE OF SCIENCE
Israël
Adresse
Herzl St.
Rehovot
AS EGEEN
Estonie
Adresse
Ã?likooli 6A
Tartu
SERONO PHARMACEUTICAL RESEARCH INSTITUTE (SPRI), A DIVISION OF SERONO INTL. S.A. (SERONO INTERNATIONAL SA)
Suisse
Adresse
14, Chemin Des Aulx
Plan-les-ouates
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Espagne
Adresse
C/serrano. 117
Madrid
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLÃ?GICAS CARLOS III
Espagne
Adresse
C/ Melchor Fernanndez Almagro, 3
Madrid
TECHNISCHE UNIVERSITAET CAROLO-WILHELMINA ZU BRAUNSCHWEIG
Allemagne
Adresse
Pockelsstrasse 14
Braunschweig
OÜ QURETEC
Estonie
Adresse
Ülikooli 6A
Tartu
COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Adresse
Batiment Le Ponant D - 25, Rue Leblanc
Paris
SWISS INSTITUTE OF BIOINFORMATICS
Suisse
Adresse
Cmu 1 Rue Michel Servet
Geneva
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
Suisse
Adresse
Postfach
Zuerich
HUMBOLDT-UNIVERSITAET ZU BERLIN
Allemagne
Adresse
Unter Den Linden 6
Berlin
UNIVERSITAET BASEL
Suisse
Adresse
Petersplatz 1
Basel
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV., REPRESENTED BY MAX PLANCK INSTITUTE OF BIOCHEMISTRY
Allemagne
Adresse
Am Klopferspitz 18
Martinsried