Objetivo A fundamental question in neurobiology is how specific behaviours are controlled at the level of molecules, cells, and neuralcircuits. In this proposal I aim to investigate how different synapses within the same neuron are specialized, how thisspecializati on contributes to, information processing in the neuron and, ultimately, to specific behavioural responses. Toinvestigate this problem I will study feeding behaviour in the nematode C. elegans. Different wild strains of C. elegans exhibitdifferent feeding strategies, which can be causally linked to the specific action of receptors, sensory neurons, andinterneurons. I will combine genome-wide RNAi screening with forward genetic approaches to identify new molecules thatcontrol how C. elegans respond to food. The function of these genes will be tested using 1. Behavioural assays, 2. Newlydeveloped labels for different post-synaptic elements in the same interneuron, and 3. Genetically encoded indicators of neuralactivity. Ultimately, I hope to understand how inf ormation received at distinct post-synaptic elements from different pre-synaptic partners sculpts neuronal output and behavioural response. Ámbito científico natural sciencesbiological sciencesneurobiologynatural scienceschemical sciencesinorganic chemistryalkaline earth metalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsagricultural sciencesagriculture, forestry, and fisheriesagricultureindustrial cropsfoddernatural sciencescomputer and information sciencesdata sciencedata processing Palabras clave Feeding behaviour RNAi genome-wide screening neural circuits neural imaging neuronal compartmentalization Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Convocatoria de propuestas FP6-2004-MOBILITY-5 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador MEDICAL RESEARCH COUNCIL Aportación de la UE Sin datos Dirección 20 Park Crescent CAMBRIDGE Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
